ABSTRACT
Systemic fungal infections are rare. In pregnancy, treatment is problematic because of the risk of possible teratogenic effects of the antifungal drugs. We present the case of a 32 year-old woman who presented during pregnancy with a two-month history of painless subcutaneous nodules. Excision biopsy of one lesion showed dematiaceous fungal elements. Anti-fungal treatment was deferred and the pregnancy proceeded uneventfully. The remaining nodules were excised at the time of caesarean section delivery. Three weeks into the puerperium, she developed generalised seizures and investigations indicated systemic fungal infection with positive cultures for Aureobasidium spp which responded to appropriate antifungal therapy of flucytosine and itraconazole.
Subject(s)
Adult , Female , Humans , Pregnancy , Pregnancy Complications, Infectious/diagnosis , Puerperal Infection/diagnosis , Ascomycota/isolation & purification , Mycosis Fungoides/diagnosis , Pregnancy Complications, Infectious/drug therapy , Puerperal Infection/drug therapy , Skin/pathology , Tomography, X-Ray Computed , Itraconazole/therapeutic use , Flucytosine/therapeutic use , Mycoses/drug therapy , Antifungal Agents/therapeutic useABSTRACT
The clinical, histological and immunohistochemical features of the first three cases of mammary hamartoma diagnosed at the University of the West Indies are reported. These tumours are innocuous and under-recognized although the mammographic features are characteristic. With increased utilization of this test in breast cancer detection in our region, it is likely that more of these legions will be identified.
Subject(s)
Adult , Female , Humans , Breast Diseases , Breast Neoplasms/pathology , Hamartoma/pathology , Mammography , JamaicaABSTRACT
Multicentric angiofollicular lymph node hyperplasia (MAFH) is a rare disorder which has been associated with various disease entities. This is the first report of its association with ulcerative colitis. details of lymph node histology and views on pathogenesis